Toxicokinetics/Toxicodynamics ofγ-Hydroxybutyrate-Ethanol Intoxication: Evaluation of Potential Treatment Strategies
نویسندگان
چکیده
منابع مشابه
Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate-ethanol intoxication: evaluation of potential treatment strategies.
γ-Hydroxybutyrate (GHB), a common drug of abuse, is often coingested with ethanol. Increasing renal clearance via monocarboxylate transporter (MCT) inhibition represents a potential therapeutic strategy in GHB overdose, as does inhibition of GABAB receptors. In this study, we investigate toxicokinetic/toxicodynamic interactions between GHB-ethanol and efficacy of treatment options for GHB-ethan...
متن کاملToxicokinetics/Toxicodynamics of g-Hydroxybutyrate-Ethanol Intoxication: Evaluation of Potential Treatment Strategies
g-Hydroxybutyrate (GHB), a common drug of abuse, is often coingested with ethanol. Increasing renal clearance via monocarboxylate transporter (MCT) inhibition represents a potential therapeutic strategy in GHB overdose, as does inhibition of GABAB receptors. In this study, we investigate toxicokinetic/ toxicodynamic interactions between GHB-ethanol and efficacy of treatment options for GHB-etha...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2013
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.113.206250